Dr. Ann Marie Egloff
Lead Investigator and Assistant Professor in Academic Cancer Research
Dr. Ann Marie Egloff was born in Owosso, Michigan, in a family emphasizing the importance of education and community service. Her mother, a dedicated sixth-grade science teacher, and her father, a public school educator and administrator, instilled in her the values of hard work and social responsibility. Growing up in this supportive environment, she excelled academically, graduating from Swartz Creek High School with honors, particularly math and science. In addition to her scholastic achievements, she was actively involved in extracurricular activities, playing varsity basketball, participating in track and field, and joining the swim team as a diver. She participated in student council, acted in theater productions, and performed ballet with the Flint Institute of Music.
Dr. Egloff’s educational journey continued at the University of Michigan, where she earned a Bachelor of Science degree in Cellular and Molecular Biology. This solid academic foundation set her on the path to a successful career in biomedical research, focusing on cancer and immunology.
The Start of a Research Career
Dr. Ann Marie Egloff began her professional research career as a Research Assistant at Warner-Lambert Parke-Davis (now part of Pfizer) in Ann Arbor, Michigan. During her time there, she received two employee recognition awards for her work on molecular cloning and the expression of therapeutic targets. Her research also evaluated small-molecule inhibitors used by cancer and metabolic disease departments. This practical experience helped her develop a strong passion for scientific inquiry, prompting her to pursue further education and training.
To deepen her knowledge, Dr. Egloff completed her PhD in Biochemistry, Cell, and Molecular Biology at the Johns Hopkins School of Medicine. Her research during this period focused on immunology and protein biochemistry, particularly examining immune cell signaling pathways that influence cellular responses. Her dissertation was centered around understanding how immune cells interact with their environment to affect disease progression, a key area that would influence her later work in cancer immunotherapy.
A Shift Towards Cancer Research
Upon completing her PhD, Dr. Ann Marie Egloff embarked on a postdoctoral fellowship at the National Human Genome Research Institute (NHGRI). There, she conducted functional studies of cancer-causing gene mutations, earning an NHGRI award for excellence in research. During her fellowship, she had the unique opportunity to witness the completion of the human genome sequence and contribute to large-scale cancer genetic screening efforts. These experiences revealed the potential of genomics to revolutionize cancer treatment, which became a driving force in her research career.
Seeking to expand her knowledge further, Dr. Egloff enrolled in the NIH/NCI-sponsored Cancer Education and Career Development Program at the University of Pittsburgh. While there, she earned a Master of Public Health in Epidemiology and focused on translational cancer research. This program equipped her with the tools to bring laboratory research into clinical practice, particularly to tailor cancer treatments to individual patients based on their unique genetic profiles. Her biomedical research and public health training gave her a broad perspective on how scientific discoveries could be translated into patient care.
Leading Innovation in Cancer Research
Dr. Ann Marie Egloff’s career progressed rapidly as she joined the University of Pittsburgh School of Medicine as a Research Associate Professor. In this role, she became a principal investigator in the Department of Otolaryngology, focusing on the genomics of head and neck squamous cell carcinoma (HNSCC). Her research investigated cancer therapeutic vulnerabilities, and she played a pivotal role in the early efforts to integrate genomic and proteomic data to guide personalized cancer treatments. Her work in this area was groundbreaking, and her research received wide recognition, leading to substantial funding from major organizations, including the NIH.
Her contributions to cancer research have had a lasting impact, particularly in developing clinical biospecimen resources. These resources enabled discoveries in biomarker research and computational analysis, furthering the understanding of cancer biology and improving therapeutic approaches. Thousands of international citations of her work reflect its significance in the field.
Boston and Beyond
In 2015, Dr. Ann Marie Egloff moved to Boston University as a Research Associate Professor and Scientific Director in the Department of Otolaryngology: Head and Neck Surgery. She helped develop research infrastructure, foster mentorship, and encourage department collaboration there. Her efforts were aimed at advancing translational research in head and neck cancer, working closely with patient advisory boards and community groups to maximize the impact of her work.
Today, Dr. Egloff continues her pioneering research at Brigham and Women’s Hospital and the Dana-Farber Cancer Institute, where she serves as a lead investigator on several high-profile projects. She is also an Assistant Professor of Surgery at Harvard Medical School. Her research focuses on tumor immunology and precision medicine approaches to cancer immunotherapy, where she explores how personalized treatments can improve patient outcomes. She works with interdisciplinary teams of surgeons, physicians, and scientists to translate her research findings into real-world clinical applications.
A Passion for Teaching and Mentorship
Dr. Ann Marie Egloff has maintained a strong commitment to education and mentorship throughout her career. She has mentored students and postdoctoral researchers at various institutions, including the University of Pittsburgh, Boston University, and Harvard Medical School. Her dedication to helping young scientists develop their careers has had a lasting impact on many researchers who have made significant contributions to the field.
In addition to her mentorship, Dr. Egloff has served as a reviewer for scientific journals and as a member of grant study sections. Her involvement in academic and professional activities has allowed her to contribute to advancing scientific knowledge and support the next generation of researchers.
Recognition and Professional Service
Dr. Ann Marie Egloff’s contributions to cancer research have earned her numerous accolades, including the NHGRI Director’s Award for Outstanding Service. She is an active member of several professional organizations, including the American Association for Cancer Research (AACR) and the American Association for the Advancement of Science (AAAS). Her involvement in these organizations allows her to stay at the forefront of cancer research and contribute to shaping the direction of the field.
A Life Rooted in Curiosity and Community
Outside of her professional endeavors, Dr. Ann Marie Egloff is deeply committed to her community in Somerville, Massachusetts. She helps organize a local community garden and volunteers for various charitable initiatives. She is also a trustee for her homeowners’ association and supports several nonprofit organizations, including Doctors Without Borders and the National Park Foundation.
Dr. Egloff enjoys biking, gardening, reading, and playing the violin in her free time. These hobbies reflect her curiosity, creativity, and commitment to personal growth, which have also influenced her scientific work and career.
A Career That’s Personal
For Dr. Egloff, science is about making a meaningful difference in people’s lives. It is not about seeking recognition but building a strong foundation for future breakthroughs and improving patient outcomes through research. Her work in cancer immunology and head and neck cancers continues to break new ground, providing hope to patients and transforming cancer treatment.
Dr. Ann Marie Egloff’s career is a testament to her dedication, thoughtfulness, and compassion. Her work continues to push the boundaries of cancer research, and her contributions to the field will have a lasting impact on cancer patients.
Dr. Egloff’s educational journey continued at the University of Michigan, where she earned a Bachelor of Science degree in Cellular and Molecular Biology. This solid academic foundation set her on the path to a successful career in biomedical research, focusing on cancer and immunology.
The Start of a Research Career
Dr. Ann Marie Egloff began her professional research career as a Research Assistant at Warner-Lambert Parke-Davis (now part of Pfizer) in Ann Arbor, Michigan. During her time there, she received two employee recognition awards for her work on molecular cloning and the expression of therapeutic targets. Her research also evaluated small-molecule inhibitors used by cancer and metabolic disease departments. This practical experience helped her develop a strong passion for scientific inquiry, prompting her to pursue further education and training.
To deepen her knowledge, Dr. Egloff completed her PhD in Biochemistry, Cell, and Molecular Biology at the Johns Hopkins School of Medicine. Her research during this period focused on immunology and protein biochemistry, particularly examining immune cell signaling pathways that influence cellular responses. Her dissertation was centered around understanding how immune cells interact with their environment to affect disease progression, a key area that would influence her later work in cancer immunotherapy.
A Shift Towards Cancer Research
Upon completing her PhD, Dr. Ann Marie Egloff embarked on a postdoctoral fellowship at the National Human Genome Research Institute (NHGRI). There, she conducted functional studies of cancer-causing gene mutations, earning an NHGRI award for excellence in research. During her fellowship, she had the unique opportunity to witness the completion of the human genome sequence and contribute to large-scale cancer genetic screening efforts. These experiences revealed the potential of genomics to revolutionize cancer treatment, which became a driving force in her research career.
Seeking to expand her knowledge further, Dr. Egloff enrolled in the NIH/NCI-sponsored Cancer Education and Career Development Program at the University of Pittsburgh. While there, she earned a Master of Public Health in Epidemiology and focused on translational cancer research. This program equipped her with the tools to bring laboratory research into clinical practice, particularly to tailor cancer treatments to individual patients based on their unique genetic profiles. Her biomedical research and public health training gave her a broad perspective on how scientific discoveries could be translated into patient care.
Leading Innovation in Cancer Research
Dr. Ann Marie Egloff’s career progressed rapidly as she joined the University of Pittsburgh School of Medicine as a Research Associate Professor. In this role, she became a principal investigator in the Department of Otolaryngology, focusing on the genomics of head and neck squamous cell carcinoma (HNSCC). Her research investigated cancer therapeutic vulnerabilities, and she played a pivotal role in the early efforts to integrate genomic and proteomic data to guide personalized cancer treatments. Her work in this area was groundbreaking, and her research received wide recognition, leading to substantial funding from major organizations, including the NIH.
Her contributions to cancer research have had a lasting impact, particularly in developing clinical biospecimen resources. These resources enabled discoveries in biomarker research and computational analysis, furthering the understanding of cancer biology and improving therapeutic approaches. Thousands of international citations of her work reflect its significance in the field.
Boston and Beyond
In 2015, Dr. Ann Marie Egloff moved to Boston University as a Research Associate Professor and Scientific Director in the Department of Otolaryngology: Head and Neck Surgery. She helped develop research infrastructure, foster mentorship, and encourage department collaboration there. Her efforts were aimed at advancing translational research in head and neck cancer, working closely with patient advisory boards and community groups to maximize the impact of her work.
Today, Dr. Egloff continues her pioneering research at Brigham and Women’s Hospital and the Dana-Farber Cancer Institute, where she serves as a lead investigator on several high-profile projects. She is also an Assistant Professor of Surgery at Harvard Medical School. Her research focuses on tumor immunology and precision medicine approaches to cancer immunotherapy, where she explores how personalized treatments can improve patient outcomes. She works with interdisciplinary teams of surgeons, physicians, and scientists to translate her research findings into real-world clinical applications.
A Passion for Teaching and Mentorship
Dr. Ann Marie Egloff has maintained a strong commitment to education and mentorship throughout her career. She has mentored students and postdoctoral researchers at various institutions, including the University of Pittsburgh, Boston University, and Harvard Medical School. Her dedication to helping young scientists develop their careers has had a lasting impact on many researchers who have made significant contributions to the field.
In addition to her mentorship, Dr. Egloff has served as a reviewer for scientific journals and as a member of grant study sections. Her involvement in academic and professional activities has allowed her to contribute to advancing scientific knowledge and support the next generation of researchers.
Recognition and Professional Service
Dr. Ann Marie Egloff’s contributions to cancer research have earned her numerous accolades, including the NHGRI Director’s Award for Outstanding Service. She is an active member of several professional organizations, including the American Association for Cancer Research (AACR) and the American Association for the Advancement of Science (AAAS). Her involvement in these organizations allows her to stay at the forefront of cancer research and contribute to shaping the direction of the field.
A Life Rooted in Curiosity and Community
Outside of her professional endeavors, Dr. Ann Marie Egloff is deeply committed to her community in Somerville, Massachusetts. She helps organize a local community garden and volunteers for various charitable initiatives. She is also a trustee for her homeowners’ association and supports several nonprofit organizations, including Doctors Without Borders and the National Park Foundation.
Dr. Egloff enjoys biking, gardening, reading, and playing the violin in her free time. These hobbies reflect her curiosity, creativity, and commitment to personal growth, which have also influenced her scientific work and career.
A Career That’s Personal
For Dr. Egloff, science is about making a meaningful difference in people’s lives. It is not about seeking recognition but building a strong foundation for future breakthroughs and improving patient outcomes through research. Her work in cancer immunology and head and neck cancers continues to break new ground, providing hope to patients and transforming cancer treatment.
Dr. Ann Marie Egloff’s career is a testament to her dedication, thoughtfulness, and compassion. Her work continues to push the boundaries of cancer research, and her contributions to the field will have a lasting impact on cancer patients.
